In the first match of van Gaal's tenure, Wayne Rooney scored twice in the first half, converting a penalty in the 42nd minute after Galaxy midfielder A.J. Delagarza handled a cross from Antonio Valencia.
Three minutes later, Los Angeles defender Tommy Meyer failed to intercept Danny Welbeck's cross, giving Rooney another chance to beat Jaime Penedo.
Welbeck had opened the scoring in the 13th minute with a 25-yard strike that crashed in off the post.
Youngster Reece James, 20, and Ashley Young added two goals apiece in the second half as the English Premier League club romped in the first match of their North American pre-season tour.
Van Gaal was tapped two months ago to replace the sacked David Moyes, but took the reins only after guiding the Netherlands to a third-place finish at the World Cup.
The 62-year-old Dutchman is tasked with restoring United to their position as the Premier League's preeminent force.
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Measurement:
